Drug Antagonism: An interaction between two or more drugs that have opposite effects on the body. Synergistic effects are when the sum of the effect is more than the two individual chemical effects combined. Symbiotic Relationships: Symbiosis means ‘living together’. Antagonism - Antagonism is the opposite of synergism. Synergism occurs when two or more hormones produce the same effects in a target cell and their results are amplified. Drug Synergism: When two drugs work together to create an effect greater than the sum of their individual effects. For this effect, 2 + 2 = 10. Among the reasons for use of antimicrobials in combination is the desire to achieve synergistic inhibitory or bactericidal activity. Eliopoulos GM(1). Synergism and antagonism. The difference between the two concepts is that Synergism is talking about the interaction of two or more substances, while Potentiation is talking about a singular substance and how it may act when in a synergy relationship. Drug antagonism may block or reduce the effectiveness of one or more of the drugs. Key Terms. The merely additive effect, due to stoichiometry, is the straight black line connecting the activity of compound A alone with that of compound B alone on the plot of the combined activity versus the mixture's composition. In synergism, the combined effect is greater than that calculated from the sum of the individual effects, and in antagonism it is smaller. antagonism: When a substance binds to the same site an agonist would bind to without causing activation of the receptor. It is a beneficial relationship between two different species in which one or both the species are benefited and neither species is harmed. ADVERTISEMENTS: Inter-specific relationships between two (or more) species can be discovered in any community and belong to two main categories —symbiosis and antagonism. Author information: (1)Harvard Medical School, Massachusetts. Antagonism occurs when a hormone opposes or reverses the effect of another hormone. It is the situation where the combined effect of two or more compounds is less toxic than the individual effects; for example: It is the situation where the combined effect of two or more compounds is less toxic than the individual effects; for example:

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